Mayor of Quahog, voiced by (and even resembles) the real life Adam West. Extremely incompetent and eccentric, he displays more than a few symptoms of delusion. He is said to be an idiot and no one knows why he became Mayor. After Lois abdicates the office of Mayor, he automatically assumes that the job is his once more. When someone questions him on this, he takes out a gun and shoots them.

Stewie is the one-year-old baby of Peter and Lois. He has an incredible vocabulary and an english accent, which he received after jumping on the bed and hitting the ceiling(This is also why he has an oddly shaped head). He is bent on murdering his mother and consistently tries. However, in the later episodes, he shows no interest of killing Lois, and uses a normal vocabulary. He has a closet with hundreds of weapons, including a time machine, and a personality-switcher, and several hundred guns and bullets.

The normal American father. Although he and his father never really had a relationship, he tries to have as a much of one as he can with his children. He often has ties and puns to everyday situations. He is quite unintelligent, and is also obese and a regular drinker.

The Griffins' paraplegic neighbor and Peter's friend. He was injured in his job as a police officer in episode "A Hero Sits Next Door". Has severe anger issues and a sexual dysfunction.

Peter's former co-worker, who has won "Employee of the Month" more than once and has since been promoted ahead of Peter. Opie is severely mentally retarded. Opie has a bad haircut, speaks unintelligibly, wears different pairs of shoes at once, enjoys biting people's fingers and has at least once shoved a pencil into his brain by inserting it into his ear and repeatedly pounding his head on his desk.

One of Peter Griffin's neighbors and friends. Currently, he owns and runs a deli. Cleveland is going to be starting his own Spin-off ruling him out as a Family Guy character.

The main correspondent for Quahog Channel 5 News. Unlike her fellow news people, Tricia displays a strong, stoic attitude. Whenever Tucker or Simmons would switch the scene to Takanawa, either of the two would always say "Asian Correspondent Tricia Takanawa", or "Asian Reporter Tricia Takanawa". She is known for her flat, nasal voice and dead-pan attitude, even when laughing and during sex. She often starts a story by naming the presenter who has just linked to her, notably in her flat nasal tone such as "Dian-ne..." or "To-om...". On one occasion, however, she completely loses control while meeting David Bowie. Diane confirms her as being Japanese, Tricia is often made to do dirty jobs, such has covering a flu segment (prompting her to throw up), and to be abused in a hurricane report. In an uncanonical episode, she is grilled and eaten by Tom and Diane. Her explosion when she met David Bowie was publicised after she started to hump his left leg like a dog. In "North by North Quahog", she is not allowed into a hotel because of her ethnicity. In some episodes of MADtv, Borstein portrays a correspondent named Sue Napersville with a similar voice.

Stewie's favorite teddy bear. Stewie treats Rupert as if he were real, and Stewie thinks he is gay. Once when waiting to board a plane he was left in charge of watching the bags, which got stolen because, according to Stewie, he was "looking at the boys again", including one who looked like Tab Hunter. Often, Stewie imagines him as an athletic man with a teddy bear's head, as seen in the episodes Stewie Loves Lois and Stewie Kills Lois. In The Man With Two Brians Stewie kills New Brian, the Griffin's new dog, after he informs Stewie that he had humped Rupert. He gets away with the murder as he forged a supposed suicide note coming from New Brian, and is seen afterwards cleaning Rupert in the shower, as some people feel dirty after being raped.

Has been featured in several cameos since his first appearance in "The Thin White Line". He can speak well, but somewhat out of tone, accentuating his parody of the hearing-impaired. He asks only that people "Don't judge me, I'm just doing my thing!" He is always shown running, even when stopped he will continue to run in place and flail his arms. In "North by North Quahog," he gives Brian drugs to plant in Jake Tucker's locker. He used to be a lawyer until he got addicted to crack. He was named Jay after an audience member by the same name in "Family Guy Live" queried his name in a Q&A Session.

An elderly ephebophile and pedophile who resides just down the street from the Griffins and impotently lusts after Chris and other young boys. He started the Quahog Boys Club.

The Griffins' next-door neighbour and Peter's friend. He is an airline pilot, but is best known for his sexual deviancies.