CAS number 129-00-0

The introduction of an article about pyripyropenes:" Fungal metabolite pyripyropenes isolated from Aspergillusfumigatus FO- 1289 were originally found to be
potent acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors. During studies on chemical modification and structure-activity relationships of pyripyropenes to develop potent ACAT inhibitors, more than 300 derivatives were synthesized. Recently, Wang et al. reported that pyripyropene A (1) was obtained from a metabolite of Eupenicillium reticulisporum NRRL3446 in the course of antiinsectan screening. Furthermore, structurally related analogs of 1 were presented as microtuble-disrupting anticancer drugs. Herein we describe the potential in reversing multidrug resistance (MDR) by pyripyropene
derivatives in drug-resistant cells."

The article is from The journal of antibiotics, 2000, 422-425 by Obata.

Currently the player with most games and SPP in my gallery of teams. He was the first player to fifty games and I hope he will reach a hundred. He aged 5th skill as an -AV. He was down with what seemed like a fatal injury in game 51 but the apothecary although drunk as always saved him nicely.

One of the original cast.

Cyclopentane [287-92-3]
Synonyms: Cyclopentane; Pentamethylene.

Mr. average boring beastman. Scored three TD's in two games and got a MVP talk about gathering SPP, but as it has happened so many times before here on fumbbl my players age quite early. FFS, he got a AG decree so he can still be used as a basher therefor the MB skill otherwise he would never skill again.

Monobromobenzene [108-86-1]
Synonyms: Bromobenzene; Monobromobenzene; Phenyl bromide.

One of the first analogs that I synthesized in my premaster project. Done by solvolysis in ethanol with and acid catalyst.

This compound was the main compound of my master thesis and I have included a part of the introduction:

Griseofulvin was first isolated from Penicillium Griseo-Fulvum in 1939 by A. E. Oxford, H. Raistrick and P. Simonart. The compound was reported a "curling factor" in 1946 and inhibits fungal mitosis by disruption of the mitotic spindle. The relative stereochemistry of griseofulvin was established in 1952 and the absolute in 1959. A crystal structure has since verified this stereochemistry. A very comprehensive study of the structure activity relationship for the antifungal activity of griseofulvin has been reported since it’s discovery. Papers were published in the fifties, the sixties but also later in 1971 and in the nineties. The
latest paper was published in 2006 with a 3D-QSAR study of griseofulvin. Several analogs were found to be more active than griseofulvin. The most potent was substituted at ring C at the 2’ and 3’ positions.
In 1996 a composition including griseofulvin was patented for inhibiting the growth of cancer. It has since been reported in 2001 and 2005 that griseofulvin induces apoptosis and cell cycle arrest in human cancer cells. In 2006 analogs of griseofulvin were tested for anticancer activity and it was reported that 2’-demethoxy-2’-propoxygriseofulvin was more active than griseofulvin itself. Recently more analogs of griseofulvin have been tested for anticancer activity and a number of 2’ enol ether analogs were more active than griseofulvin.

From wikipedia:

Diketopiperazines (DKP) are a class of cyclic organic compounds that result from peptide bonds between two amino acids to form a lactam. They are the smallest possible cyclic peptides.
A diketopiperazine was the first peptide to have its complete three-dimensional structure described, in work undertaken at Caltech by Robert Corey in the 1930s. Corey studied the cyclic anhydride of the dipeptide glycyl glycine.
Diketopiperazines are commonly biosynthesized from amino acids by different organisms, including mammals, and are considered to be secondary metabolites. Some protease enzymes, such as dipeptidyl peptidases, cleave the terminal ends of proteins to generate dipeptides which naturally cyclize to form diketopiperazines.
Due to their rigid structure, chiral nature, and varied side chains, diketopiperazines are an attractive scaffold for drug design. Both natural and synthetic diketopiperazines have a wide variety of biological activities including antitumor, antiviral, antifungal and antibacterial activities.

A reagent used for olefin metathesis. Two more generations have been invented and will be used for later big guys I think.

Here is what wiki writes about the inventor:

Robert Howard Grubbs (b. 27 February 1942 in Possum Trot, Kentucky) is an American chemist and Nobel laureate.
As he noted in his official Nobel Prize autobiography, "In some places, my birthplace is listed as Calvert City and in others Possum Trot [NB: both in Marshall County]. I was actually born between the two, so no one really is correct." He spent his early childhood in Marshall County and attended public school at McKinley Elementary, Franklin Junior High and Paducah Tilghman High School in Paducah, Kentucky. Grubbs studied chemistry at the University of Florida (B.S. and M.S.), where he worked with Merle Battiste, and Columbia University, where he obtained his Ph.D. under Ronald Breslow in 1968.
He next spent a year with James Collman at Stanford University. He was then appointed to the faculty of Michigan State University. In 1978 he moved to California Institute of Technology where he is presently Victor and Elizabeth Atkins Professor of Chemistry.
His main interests in organometallic chemistry and synthetic chemistry are catalysts, notably Grubbs' catalyst for olefin metathesis and ring-opening metathesis polymerization with cyclic olefins such as norbornene. He also contributed to the development of so-called "living polymerization".
Grubbs's many awards have included: Alfred P. Sloan Fellow (1974-76), Camille and Henry Dreyfus Teacher-Scholar Award (1975-78), Alexander von Humboldt Fellowship (1975), ACS Benjamin Franklin Medal in Chemistry (2000), ACS Herman F. Mark Polymer Chemistry Award (2000), ACS Herbert C. Brown Award for Creative Research in Synthetic Methods (2001) and the Nobel Prize in Chemistry (2005). He was elected to the National Academy of Sciences in 1989 and a fellowship in the American Academy of Arts and Sciences in 1994.
Grubbs received the 2005 Nobel Prize in Chemistry, along with Richard R. Schrock and Yves Chauvin, for his work in the field of olefin metathesis.
Grubbs is married to Helen Grubbs (née O'Kane), a retired SLP elementary school teacher,[1] with three children—all are professors or PhDs.